Kallikreins Stepwise Scoring Reveals Three Subtypes of Papillary Thyroid Cancer with Prognostic Implications

Buj R, Mallona I, Díez-Villanueva A, Zafon C, Mate JL, Roca M, Puig-Domingo M, Reverter JL, Mauricio D, Peinado MA, Jordà M

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The Pancancer DNA Methylation Trackhub: A Window to The Cancer Genome Atlas Epigenomics Data.

Mallona I, Sierco A, Peinado MA. The Pancancer DNA Methylation Trackhub: A Window to The Cancer Genome Atlas Epigenomics Data. Methods Mol Biol. 2018;1766:123-135. doi: 10.1007/978-1-4939-7768-0_7.

Continue reading “The Pancancer DNA Methylation Trackhub: A Window to The Cancer Genome Atlas Epigenomics Data.”

CpG Islands. Methods and Protocols

CpG islands constitute key genomic elements playing a fundamental role in essential biological processes such as development and cell differentiation. CpG islands are short stretches of DNA enriched in CpG dinucleotides, firstly identified by Adrian Bird in the 80’s. The human genome contains about 28,000 of these elements that are tightly associated to the regulation of 40% of the genes. Epigenetic alterations of specific CpG islands constitute molecular landmarks of multiple diseases including cancer, cardiovascular and neurological diseases, becoming principal targets as biomarkers and advanced therapeutic strategies.

The authoritative series Methods in Molecular Biology published by Springer Nature has released a new volume devoted to cover different aspects related with the study of these genomic elements. The book covers bioinformatic and molecular biology methods useful to identify and to explore the functions of CpG islands, as well as reviews on key applications of its study. Tanya Vavouri and Miguel A. Peinado, from the IJC and the IGTP, are the editors and have counted with the contribution of internationally renowned scientists in the fields of genomics and epigenomics.

The book contents and the online version may be found at: https://link.springer.com/book/10.1007/978-1-4939-7768-0.

Reference: Vavouri T, Peinado MA (ed.) CpG Islands: Methods and Protocols. Methods Mol Biol. 2018;1766. https://doi.org/10.1007/978-1-4939-7768-0

Increased global DNA hypomethylation in distant metastatic and dedifferentiated thyroid cancer.

Klein Hesselink EN, Zafon C, Villalmanzo N, Iglesias C, van Hemel BM, Klein Hesselink MS, Montero-Conde C, Buj R, Mauricio D, Peinado MA, Puig-Domingo M, Riesco-Eizaguirre G, Reverter JL, Robledo M, Links TP, Jordà M. Increased global DNA hypomethylation in distant metastatic and dedifferentiated thyroid cancer. J Clin Endocrinol Metab. 2018 Feb 1;103(2):397-406. doi: 10.1210/jc.2017-01613.

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Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis.

Ejarque M, Ceperuelo-Mallafré V, Serena C, Pachón G, Núñez-Álvarez Y, Terrón-Puig M, Calvo E, Núñez-Roa C, Oliva-Olivera W, Tinahones FJ, Peinado MA, Vendrell J, Fernández-Veledo S. Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis. Cell Death Dis. 2017 May 18;8(5):e2802. doi: 10.1038/cddis.2017.209.

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Chainy, an universal tool for standardized relative quantification in real-time PCR.

Mallona I, Díez-Villanueva A, Martín B, Peinado MA.  Chainy, an universal tool for standardized relative quantification in real-time PCR. Bioinformatics. 2017 May 1;33(9):1411-1413. doi: 10.1093/bioinformatics/btw839.

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