CpG islands constitute key genomic elements playing a fundamental role in essential biological processes such as development and cell differentiation. CpG islands are short stretches of DNA enriched in CpG dinucleotides, firstly identified by Adrian Bird in the 80’s. The human genome contains about 28,000 of these elements that are tightly associated to the regulation of 40% of the genes. Epigenetic alterations of specific CpG islands constitute molecular landmarks of multiple diseases including cancer, cardiovascular and neurological diseases, becoming principal targets as biomarkers and advanced therapeutic strategies.
The authoritative series Methods in Molecular Biology published by Springer Nature has released a new volume devoted to cover different aspects related with the study of these genomic elements. The book covers bioinformatic and molecular biology methods useful to identify and to explore the functions of CpG islands, as well as reviews on key applications of its study. Tanya Vavouri and Miguel A. Peinado, from the IJC and the IGTP, are the editors and have counted with the contribution of internationally renowned scientists in the fields of genomics and epigenomics.
The book contents and the online version may be found at: https://link.springer.com/book/10.1007/978-1-4939-7768-0.
Reference: Vavouri T, Peinado MA (ed.) CpG Islands: Methods and Protocols. Methods Mol Biol. 2018;1766. https://doi.org/10.1007/978-1-4939-7768-0
We are assembling an interdisciplinary group to develop a collaborative project between academia and private entrepreneurship and welcome creative people from diverse backgrounds. Our project aims to bring the advances of Genomics and Epigenomics technologies to routine applications in health and biomedical research. Please visit our web sites for more information about our work.
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We are looking for a bionformatician to be responsible of the computational analysis of epigenetic changes in genome-scale projects using in-house developed next generation sequencing technology. The ultimate goal of the project is the improvement of genomic tools to analyze genetic and epigenetic variations in cancer and other diseases.
A good background on the analysis of epigenetic modifications, especially methylation, using NGS technologies is highly desirable, as well as experience in job scheduling in grid/cloud computing. Proven proficiency in the management of Biological Databases, programming languages (R, Perl, C++, Python, etc.) and statistical methods is required.
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La revista Genética Médica (5 de marzo de 2016) incluye una reseña en español sobre el artículo de Raquel Buj publicado en Oncotarget.