JOB POSITION: Scientific Coordinator (ref. 2019/24)

We are seeking an enthusiastic Scientific Coordinator to manage a collaborative project “GEUS” aimed to bring advances in Genomics and Epigenomics to research and medical applications. The project is a partnership between academic institutions and the biotech industry.

Continue reading “JOB POSITION: Scientific Coordinator (ref. 2019/24)”

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis

Tao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O’Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Chiu Yen RW, Shao X, Thakor J, Lu Z, Cai Y, Zhang Y, Mallona I, Peinado MA, Zahnow CA, Ahuja N, Fertig E, Issa JP, Baylin SB, Easwaran H.

Cancer Cell. 2019 Feb 11;35(2):315-328.e6. doi: 10.1016/j.ccell.2019.01.005.


We addressed the precursor role of aging-like spontaneous promoter DNA hypermethylation in initiating tumorigenesis. Using mouse colon-derived organoids, we show that promoter hypermethylation spontaneously arises in cells mimicking the human aging-like phenotype. The silenced genes activate the Wnt pathway, causing a stem-like state and differentiation defects. These changes render aged organoids profoundly more sensitive than young ones to transformation by BrafV600E, producing the typical human proximal BRAFV600E-driven colon adenocarcinomas characterized by extensive, abnormal gene-promoter CpG-island methylation, or the methylator phenotype (CIMP). Conversely, CRISPR-mediated simultaneous inactivation of a panel of the silenced genes markedly sensitizes to BrafV600E-induced transformation. Our studies tightly link aging-like epigenetic abnormalities to intestinal cell fate changes and predisposition to oncogene-driven colon tumorigenesis.

Graph abstract

See paper at journal site

Continue reading “Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis”

Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.

Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L.

World J Gastroenterol. 2019 Jan 28;25(4):433-446. doi: 10.3748/wjg.v25.i4.433.

Continue reading “Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.”


Main Responsibilities

The individual in this position will be responsible for computational biology and bioinformatics support of genome-scale projects using advanced genomic technologies including in-house developed NGS methods. The major goal of the project is the obtention of genome-scale maps of epigenetic variation in human populations and disease. The project is highly collaborative and provides the opportunity to interact with investigators in different disciplines, including computational and experimental biology.

Primary duties will include, but will not be limited, to the design and implementation of algorithms to map, annotate, integrate and organize data generated by next generation sequencing instruments, and  downstream statistical analyses and validation. Duties will also include data-mining on high-throughput data sets and development of tools for data analysis, integration and visualization.


Background: PhD in Bioinformatics, Computer Science, Biology,  Mathematics, or a related field. Experience in biomedical computing. Proven proficiency in the management of Biological Databases, programming languages (R, Perl, Java, C++, Python, etc.) and biostatistics methods is required.

What we offer

  • A contract for a period of 12 months with possibility of extension
  • Competitive salary according to qualifications and experience
  • Integration in a collaborative scientific network devoted to high quality research in the field of cancer genomics and epigenomics
  • Dynamic interaction with other leading cancer research groups
  • Interaction with other bioinformatics groups within and outside of the institution
  • Possibility for career advancement and attendance to specialized training courses and scientific meetings

Additional information

For more information on the research of the Mechanisms of Cancer and Cell Differentiation group visit the web page at or write to Miguel A. Peinado at

Deadline for applications: 30 October 2018

How to apply

Interested applicants should send the following documents to and

  • A short statement of motivation
  • A CV including your contact details
  • Names, email and telephone numbers of two referees


PLEASE INDICATE THE REFERENCE 2018/113 in the subject of the mail.




CpG Islands. Methods and Protocols

CpG islands constitute key genomic elements playing a fundamental role in essential biological processes such as development and cell differentiation. CpG islands are short stretches of DNA enriched in CpG dinucleotides, firstly identified by Adrian Bird in the 80’s. The human genome contains about 28,000 of these elements that are tightly associated to the regulation of 40% of the genes. Epigenetic alterations of specific CpG islands constitute molecular landmarks of multiple diseases including cancer, cardiovascular and neurological diseases, becoming principal targets as biomarkers and advanced therapeutic strategies.

The authoritative series Methods in Molecular Biology published by Springer Nature has released a new volume devoted to cover different aspects related with the study of these genomic elements. The book covers bioinformatic and molecular biology methods useful to identify and to explore the functions of CpG islands, as well as reviews on key applications of its study. Tanya Vavouri and Miguel A. Peinado, from the IJC and the IGTP, are the editors and have counted with the contribution of internationally renowned scientists in the fields of genomics and epigenomics.

The book contents and the online version may be found at:

Reference: Vavouri T, Peinado MA (ed.) CpG Islands: Methods and Protocols. Methods Mol Biol. 2018;1766.


We are assembling an interdisciplinary group to develop a collaborative project between academia and private entrepreneurship and welcome creative people from diverse backgrounds. Our project aims to bring the advances of Genomics and Epigenomics technologies to routine applications in health and biomedical research. Please visit our web sites for more information about our work.



We are looking for a bionformatician to be responsible of the computational analysis of epigenetic changes in genome-scale projects using in-house developed next generation sequencing technology.  The ultimate goal of the project is the improvement of genomic tools to analyze genetic and epigenetic variations in cancer and other diseases.

A good background on the analysis of epigenetic modifications, especially methylation, using NGS technologies is highly desirable, as well as experience in job scheduling in grid/cloud computing. Proven proficiency in the management of Biological Databases, programming languages (R, Perl, C++, Python, etc.) and statistical methods is required.

Conditions: Salary will be internationally competitive.

How to apply: Please send your application to and copy to:

Applications should include:

  • A CV including your contact details
  • Names, email and telephone number of at least two referees
  • A short statement of motivation



Position posted: January 2017

Last date for Applications: 15th February 2017