More papers (2014 and older)

2014

  • Huertas-Martínez J, Rello-Varona S, Herrero-Martín D, Barrau I, García-Monclús S, Sáinz-Jaspeado M, Lagares-Tena L, Núñez-Álvarez Y, Mateo-Lozano S, Mora J, Roma J, Toran N, Moran S, López-Alemany R, Gallego S, Esteller M, Peinado MA, Del Muro XG, Tirado OM. Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth. Oncotarget, 5:9744-55, 2014.
  • Mallona I, Díez-Villanueva A, Peinado MA. Methylation plotter: a web tool for dynamic visualization of DNA methylation data. Source Code in Biology and Medicine, 9:11. doi: 10.1186/1751-0473-9-11, 2014.
  • Mancikova V, Buj R, Castelblanco E, Inglada-Pérez L, Diez A, de Cubas AA, Curras-Freixes M, Maravall FX, Mauricio D, Matias-Guiu X, Puig-Domingo M, Capel I, Bella MR, Lerma E, Castella E, Reverter JL, Peinado MÁ, Jorda M, Robledo M. DNA methylation profiling of well-differentiated thyroid cancer uncovers markers of recurrence free survival. International Journal of Cancer, 135:598-610, 2014.

2013

  • Carrió E, Díez-Villanueva A, Lois S, Mallona I, Cases I, Forn M, Peinado MA, Forn M, Muñoz M, Tauriello DV, Merlos-Suárez A, Rodilla V, Bigas A, Batlle E, Jordà M, Peinado MA. Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells. Molecular Oncology, 7:1129-1141, 2013.
  • Ginestà MM, Mora J, Mayor R, Farré A, Peinado MA, Busquets J, Serrano T, Capellá G, Fabregat J. Genetic and epigenetic markers in the evaluation of pancreatic masses. Journal of Clinical Pathology, 66:192-197, 2013.

2012

  • Gomez-Diaz E, Jordà M, Peinado MA, Rivero A. Epigenetics of host-pathogen interactions: the road ahead and the road behind. PLOS Pathogens, e1003007, 2012.
  • Barrera V, Peinado MA. Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale. Nucleic Acids Research, 40:11490-11498, 2012.
  • Cebola I, Peinado MA. Epigenetics of the COX pathway in cancer. Progress in Lipid Research 51:301-313, 2012.

2011

  • Mayor R, Muñoz M, Coolen MW, Custodio J, Esteller M, Clark SJ, Peinado MA. Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. Epigenetics 6:1138-1148, 2011.
  • Devaney J, Stirzaker C, Qu W, Song JZ, Statham AL, Patterson KI, Horvath LG, Tabor B, Coolen MW, Hulf T, Kench JG, Henshall SM, Pe Benito R, Haynes AM, Mayor R, Peinado MA, Sutherland RL, Clark SJ. Epigenetic deregulation across 2q14.2 differentiates normal from prostate cancer and provides a regional panel of novel DNA methylation cancer biomarkers. Cancer Epidemiology, Biomarkers & Prevention 20:148-159, 2011.

2010

  • Cebola I, Peinado MA. PTGIS (prostaglandin I2 (prostacyclin) synthase). Atlas Genet Cytogenet Oncol Haematol; 14(4) 418-420, 2010. http://atlasgeneticsoncology.org/Genes/PTGISID44219ch20q13.html
  • Jordà M, Peinado MA. Methods for DNA methylation analysis and applications in colon cancer. Mutation Research 693:84-93, 2010.
  • Azuara D, Rodriguez-Moranta F, de Oca J, Soriano-Izquierdo A, Mora J, Guardiola J, Biondo S, Blanco I, Peinado MA, Moreno V, Esteller M, Capellá G. Novel methylation panel for the early detection of colorectal tumors in stool DNA. Clinical Colorectal Cancer 9:168-176, 2010.
  • Javierre BM, Fernandez AF, Richter J, Al-Shahrour F, Martin-Subero JI, Rodriguez-Ubreva J, Berdasco M, MFraga MF, O’Hanlon TP, Rider LG, Jacinto FV, Lopez-Longo FJ, Dopazo J, Forn M, Peinado MA, Carreño L, Sawalha AH, Harley JB, Siebert R, Esteller M, Miller FW, Ballestar E. Changes in the Pattern of DNA Methylation Associate with Twin Discordance in Systemic Lupus Erythematosus. Genome Research, 20:170-179, 2010.

2009

  • Jordà M, Peinado MA. Gene regulation of the social behavior in the honeybee (in Spanish). Investigación y Ciencia, 395:40-43, 2009.
  • Mayor R, Casadomé L, Azuara D, Moreno V, Clark SJ, Capellà G, Peinado MA. Long range epigenetic silencing in 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. British Journal of Cancer, 100:1534-1539, 2009.
  • Gómez-Díaz E, González-Solís J, Peinado MA. Population structure in a highly pelagic seabird, the Cory’s shearwater (Calonectris diomedea): an examination of genetics, morphology and ecology. Marine Ecology Progress Series, 382:197-209, 2009.
  • Morales C, García MJ, Ribas M, Miró R, Muñoz M, Caldas C, Peinado MA. DHFR amplification and sensitization to methotrexate of methotrexate resistant colon cancer cells. Molecular Cancer Therapeutics, 8:424-432, 2009.

2008

  • Rodriguez J, Muñoz M, Vives L, Frangou CG, Groudine M, Peinado MA. Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells. Proceedings of the National Academy of Sciences USA, 105:19809-19814, 2008.
  • Selga E, Morales C, Noe V, Peinado MA, Ciudad CJ. Role of Caveolin 1, E-Cadherin, Enolase 2 and PKC alpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Medical Genomics, 1:35, 2008.
  • Rodriguez J, Vives L, Jordà M, Morales C, Muñoz M, Vendrell E, Peinado MA. Genome-wide tracking of unmethylated DNA Alu repeats in normal and cancer cells. Nucleic Acids Research, 36:770-784, 2008.
  • Valls J, Grau M, Sole X, Hernandez P, Montaner D, Dopazo J, Peinado MA, Capella G, Pujana MA, Moreno V. CLEAR-test: Combining inference for differential expression and variability in microarray data analysis. Journal of Biomedical Informatics, 41:33-45, 2008.

2007

  • Gómez-Díaz E, Gonzalez-Solís J, Peinado MA, Page DM. Lack of host-dependent genetic structure in ectoparasites of Calonectris shearwaters. Molecular Ecology, 16:5204-5215, 2007.
  • Vendrell E, Ribas M, Valls J, Solé X, Grau M, Moreno V, Capellà G, Peinado MA. Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. International Journal of Oncology, 30:1099-1107, 2007.
  • Alazzouzi H, Suriano G, Guerra A, Plaja A, Espín E, Armengol M, Alhopuro P, Velho S, Shinomura Y, González-Aguilera JJ, Yamamoto H, Aaltonen LA, Moreno V, Capellà G, Peinado MA, Seruca R, Arango D, Schwartz Jr S. Tumor selection advantage of non-dominant negative p53 mutations in homozygous mdm2-snp309 colorectal cancer cells. Journal of Medical Genetics, 44:75-80, 2007.

2006

  • Wang Y, Jordà M, Jones PL, Maleszka R, Ling X, Robertson HM, Mizzen CA, Peinado MA, Robinson GE. Functional CpG methylation system in a social insect. Science, 314:645-647, 2006.
  • The Honeybee Genome Sequencing Consortium (…, Jordà M, Peinado MA,…). Insights into social insects from the genome of the honeybee Apis mellifera. Nature, 443:931-949, 2006.
  • Gómez-Díaz E, González-Solís J, Peinado MA, Page RDM. Phylogeography of the Calonectris shearwaters using molecular and morphometric data. Molecular Phylogenetics and Evolution, 41:322-332, 2006.
  • Rodriguez J, Frigola J, Vendrell E, Risques RA, Fraga MF, Morales C, Moreno V, Esteller M, Capellà G, Ribas M, Peinado MA. Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Research, 66:8462-8468, 2006.
  • Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA, Clark SJ. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nature Genetics, 38:540-549, 2006.
  • Iacopetta B, Russo A, Bazan V, Dardanoni G, Gebbia N, Soussi T, Kerr D, Elsaleh H, Soong R, Kandioler D, Janschek E, Kappel S, Lung M, Leung CS, Ko JM, Yuen S, Ho J, Leung SY, Crapez E, Duffour J, Ychou M, Leahy DT, O’donoghue DP, Agnese V, Cascio S, Di Fede G, Chieco-Bianchi L, Bertorelle R, Belluco C, Giaretti W, Castagnola P, Ricevuto E, Ficorella C, Bosari S, Arizzi CD, Miyaki M, Onda M, Kampman E, Diergaarde B, Royds J, Lothe RA, Diep CB, Meling GI, Ostrowski J, Trzeciak L, Guzinska-Ustymowicz K, Zalewski B, Capella GM, Moreno V, Peinado MA, Lonnroth C, Lundholm K, Sun XF, Jansson A, Bouzourene H, Hsieh LL, Tang R, Smith DR, Allen-Mersh TG, Khan ZA, Shorthouse AJ, Silverman ML, Kato S, Ishioka C. Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study. Annals of Oncology, 17:842-847, 2006.
  • Masramon L, Vendrell E, Tarafa G, Capellà G, Miró R, Ribas M, Peinado MA. Genetic instability and divergence of clonal populations in colon cancer cells in vitro. Journal of Cell Science, 119:1477-1482, 2006.
  • Dotor E, Cuatrecases M, Martínez-Iniesta M, Vilardell F, Navarro M, Pareja L, Guinó E, Figueras A, Serrano T, de Oca J, Peinado MA, Moreno V, Germà JR, Capella G, Villanueva A. Tumor Thymidylate Synthase 1494 del6 genotype as a prognostic factor in colorectal cancer patients receiving 5-FU-based adjuvant treatment. Journal of Clinical Oncology, 24:1603-1611, 2006.
  • Muñoz J, Vendrell E, Aiza G, Nistal M, Pestaña A, Peinado MA, Castresana JS. Determination of genomic damage in neuroblastic tumors by arbitrarily primed PCR: MYCN amplification as a marker for genomic instability in neuroblastomas. Neuropathology 26:165–169, 2006.
  • Morales C, Peinado MA. Inestabilidad de microsatélites: papel diagnóstico e implicaciones pronósticas. GH Continuada, 5:18-22, 2006.

2005

  • Frigola J, Muñoz M, Clark SJ, Moreno V, Capellà G, Peinado MA. Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy. Oncogene, 24:7320-7326, 2005.
  • Morales C, Ribas M, Aiza G, Peinado MA. Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells. Oncogene, 24:6842-6847, 2005.
  • Vendrell E, Morales C, Risques RA, Capellà G, Peinado MA. Genomic determinants of prognosis in colorectal cancer. Cancer Letters, 221:1-9, 2005.
  • Camps J, Ponsa I, Ribas M, Prat E, Egozcue J, Peinado MA, Miró R. Comprehensive measurement of chromosomal instability in cancer cells: Combination of FISH and cytokinesis-block micronucleus assay. FASEB Journal, 19:828-830, 2005.
  • Frigola J, Solé X, Paz MF, Moreno V, Esteller M, Capellà G, Peinado MA. DNA hypermethylation and hypomethylation signatures in colorectal cancer. Human Molecular Genetics, 14:319-326, 2005.
  • Mendez O, Fernandez Y, Peinado MA, Moreno V, Sierra A. Anti-apoptotic proteins induce non-random genetic alterations that result in selecting breast cancer metastatic cells. Clininal & Experimental Metastasis, 22:297-307, 2005.
  • Grau M, Solé X, Obrador A, Tarafa G, Vendrell E, Valls J, Moreno V, Peinado MA, Capellà G. Validation of RNA Arbitrarily-Primed PCR (RAP-PCR) probes hybridized to glass cDNA microarrays. Application to the analysis of small samples. Clinical Chemistry, 51:93-101, 2005.

2004

  • Howsam M, Grimalt JO, Guinó E, Navarro M, Cambray M, Martí-Ragué J, Peinado MA, Capella G, Moreno V. Organochlorine exposure and colorectal cancer risk. Environmental Health Perspectives, 112:1460-1466, 2004.
  • Menéndez M, González S, Blanco I, Guinó E, Peris M, Peinado MA, Capella G, Moreno V. Colorectal cancer risk and the APC D1822V variant. International Journal of Cancer, 112:161-163, 2004.
  • Camps J, Morales C, Prat E, Ribas M, Capella G, Egozcue J, Peinado MA, Miró R. Genetic evolution in colon cancer KM12 cells and metastatic derivates. International Journal of Cancer, 110:869-874, 2004.
  • Musulén E, Moreno V, Reyes G, Sancho FJ, Peinado MA, Esteller M, Herman JG, Combalia N, Rey M, Capellà G. Standardized approach for microsatellite instability detection in gastric carcinomas. Human Pathology, 35:335-342, 2004.
  • Gemignani F, Moreno V, Landi S, Moullan N, Chabrier A, Gutièrrez-Enriquez S, Hall J, Guino E, Peinado MA, Capella G, Canzian F. A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA. Oncogene, 23:1954-1956, 2004.

2003

  • Risques RA, Moreno V, Ribas M, Marcuello E, Capella G, Peinado MA. Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer. Cancer Research, 63:7206-7214, 2003.
  • Tarafa G, Prat E, Risques RA, González S, Camps J, Grau M, Guinó E, Moreno V, Esteller M, Herman G, Germà JR, Miró R, Peinado MA, Capellá G. Common genetic evolutionary pathways in familial adenomatous polyposis tumors. Cancer Research, 63:5731-5737, 2003.
  • Risques RA, Ribas M, Peinado MA. Assessment of cumulated genetic alterations in colorectal cancer. Histology and Histopathology, 18: 1289-1299, 2003 .
  • Paz MF, Wei S, Cigudosa JC, Rodriguez-Perales S, Peinado MA, Huang THM, Esteller M. Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. Human Molecular Genetics, 12: 2209-2219, 2003.
  • Ribas M, Masramon L, Aiza G, Miró R, Capellà G, Peinado MA. The structural nature of chromosomal instability in colon cancer cells. FASEB Journal, 17: 289-291, 2003.

2002

  • Moreno V, Guino E, Bosch FX, Peinado M, Capellà G, Navarro M, Martí J, Cambray M, Lloveras B, Bellvitge Colorectal Cancer Study Group. Diet and K-ras mutations in colorectal cancer. IARC Sci 156: 501-502, 2002.
  • Esteller M, Guo M, Moreno V, Peinado MA, Capella G, Galm O, Baylin SB, Herman JG. Hypermethylation-Associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer. Cancer Research, 62: 5902-5905, 2002.
  • Paz MF, Avila S, Fraga MF, Pollan M, Capella G, Peinado MA, Sanchez-Cespedes M, Herman JG, Esteller M. Germline Variants in Methyl-Group Metabolism Genes and Susceptibility to DNA Methylation in Normal Tissues and Human Primary Tumors. Cancer Research, 62: 4519-4524, 2002.
  • Palicio M, Balmaña J, González S, Blanco I, Marcuello E, Peinado MA, Julià G, Germà JR, López López JJ, Brunet J, Capellà G. Mismatch repair gene analysis in Catalonian families with colorectal cancer. Journal of Medical Genetics, 39: e29, 2002.
  • Frigola J, Ribas M, Risques RA, Peinado MA. Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS). Nucleic Acids Research, 30: e28-8, 2002.

2001

  • Armengol G, Capella G, Farre L, Peinado MA, Miro R, Caballin MR. Genetic Evolution in the Metastatic Progression of Human Pancreatic Cancer Studied by CGH. Laboratory Investigation, 81: 1703-1707, 2001.
  • Esteller M, Fraga MF, Guo M, Garcia-Foncillas J, Hedelfank I, Godwin AK, Trojan J, Vaurs-Barrière C, Bignon Y-J, Ramus S, Benitez J, Akiyama Y, Caldes T, Canal MJ, Rodriguez R, Capella G, Peinado MA, Borg A, Aaltonen LA, Ponder BA, Baylin SB, Herman JG. DNA methylation patterns in hereditary human cancer mimics sporadic tumorigenesis. Human Molecular Genetics, 10: 3001-3007, 2001.
  • Esteller M, Risques RA, Toyota M, Capella G, Moreno V, Peinado MA, Baylin SB, Herman JG. Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Research, 61: 4689-4692, 2001.
  • Tortola S, Steiner R, Hantschick M, Peinado MA, Gastinger I, Stosiek P, Lippert P, Schlegel W, Reymond MA. Bone marrow micrometastases in colorectal cancer do not always carry the same k-ras mutations as the primary tumor. Journal of Clinical Oncology, 19: 2837-2843, 2001.
  • Esteller M, Cordon-Cardo C, Corn PG, Meltzer SJ, Watkins NG, Capella G, Peinado MA, Matias-Guiu X, Prat J, Baylin SB, Herman JG. p14 ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. Cancer Research, 61: 2816-2821, 2001.
  • Mendez O, Mañas S, Peinado MA, Fabra A, Escobedo A, Moreno A, Sierra A. Microsatellite instability is associated with the loss of apoptosis in ductal breast carcinomas. Breast Cancer Research and Treatment, 65: 171-177, 2001.
  • Risques RA, Moreno V, Marcuello E, Petriz J, Cancelas JA, Sancho FJ, Torregrosa A, Capellà G, Peinado MA. Redefining the significance of aneuploidy in the prognostic assessment of colorectal cancer. Laboratory Investigation, 81: 307-315, 2001.
  • Esteller M, González S, Risques RA, Marcuello E, Mangues R, Germà JR, Herman JG, Capellà G, Peinado MA. K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. Journal of Clinical Oncology, 19: 299-304, 2001.

2000

  • Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Gonzalez S, Tarafa G, Sidransky D, Meltzer S, Baylin SB, Herman JG. Analysis of APC promoter hypermethylation in human cancer. Cancer Research, 60: 4366-4371, 2000.
  • Masramon L, Ribas M, Cifuentes P, Arribas R, García F, Egozcue J, Peinado MA, Miró R. Cytogenetic characterization of two colon cell lines using conventional G-banding, Comparative Genome Hybridization (CGH) and Whole Chromosome Painting (WCP). Cancer Genetics and Cytogenetics, 121: 17-21, 2000.
  • Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN, Issa JPJ, Sidransky D, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation Is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Research, 60: 2368-2371, 2000.
  • González-García I, Moreno V, Navarro M, Martí-Ragué J, Marcuello E, Benasco C, Campos O, Capellà G, Peinado MA. Standardized approach for microsatellite instability detection in colorectal carcinomas. Journal of the National Cancer Institute, 92: 544-549, 2000.
  • Palicio M, Blanco I, Tortola S, Gonzalez I, Marcuello E, Brunet J, Lluis F, Gonzalez-Aguilera JJ, Peinado MA, Capella G. Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer. British Journal of Cancer, 82: 535-537, 2000.
  • Tarafa G, Villanueva A, Farré L, Rodríguez J, Musulén E, Reyes G, Puig P, Seminago R, Olmedo E, Paules AB, Peinado MA, Bachs O, Capella G. DCC and smad4 alterations in human colorectal and pancreatic tumor dissemination. Oncogene, 19: 546-555, 2000.
  • Esteller M, Tortola S, Toyota M, Capella G, Peinado MA, Baylin SB, Herman JG. Hypermethylation-associated inactivation of p14ARF suggests a tumor suppressor role independent of p16INK4A and p53 status. Cancer Research, 60:129-133, 2000.

1999

  • Arribas R, Ribas M, Risques RA, Masramon LA, Tórtola S, Marcuello E, Aiza G, Miró R, Capellà G, Peinado MA. Prospective assessment of allelic losses at 4p14-16 in colorectal cancer: two mutational patterns and a locus associated with poorer survival. Clinical Cancer Research, 5:3454-3459, 1999.
  • Tórtola S, Marcuello E, Risques RA, Gonzalez S, Aiza G, Capellà G, Peinado MA. Overall deregulation in gene expression as a novel indicator of tumor aggressiveness in colorectal cancer. Oncogene, 30:4383-4387, 1999.
  • Masramon L, Risques RA, Arribas R, Peinado MA. Detection of genetic alterations in tumor cells by Arbitrarily Primed PCR. Biotech Lab International, 4:6-9, 1999.
  • Tortola S, Marcuello E, Gonzalez S, Reyes G, Arribas R, Aiza G, Sancho J, Peinado MA, Capella G. p53 and K-ras mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. Journal of Clinical Oncology, 17:1375-1381, 1999.
  • Arribas R, Risques RA, Gonzalez-García I, Masramon L, Aiza G, Ribas M, Capellà G, Peinado MA. Tracking recurrent quantitative genomic alterations in colorectal cancer: Allelic losses in chromosome 4 correlate with tumor aggressiveness. Laboratory Investigation, 79:111-122, 1999.
  • Vinyals A, Peinado MA, Gonzalez-Garrigues M, Monzó M, Bonfil R.D. Fabra A. Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein. Gene Therapy, 6:22-33, 1999.

1998

  • Vinyals A, Alia P, Llorens A, Adrover M, Gonzalez-Garrigues M, Masramon L, Peinado MA, Fabra A. Detection of differentially expressed gelatinase A in metastatic and non-metastatic subpopulations of tumor cells by target RNA arbitrarily primed polymerase chain reaction (TRAP-PCR). Clinical & Experimental Metastasis, 16:603-611, 1998.
  • Arribas R, Masramon L, Peinado MA. Application of the arbitrarily primed PCR. The analysis of tumor genetic alterations. Bioforum International 2:77-81, 1998.
  • Masramon L, Arribas R, Tórtola S, Perucho M, Peinado MA. Moderate amplifications of the c-myc gene correlate with molecular and clinico-pathological parameters in colorectal cancer. British Journal of Cancer, 77:2349-2356, 1998.
  • De Juan C, Iniesta P, Vega FJ, Peinado MA, Fernandez C, Caldés T, Massa MJ, López JA. Sánchez A, Torres AJ, Balibrea JL, Benito M. Prognostic value of genomic damage in non-small cell lung cancer. British Journal of Cancer, 77:1971-1977, 1998.
  • Cazorla M, Hernandez L, Fernandez PL, Fabra A, Peinado MA, Dasenbrock C, Tillman T, Kamino K, Campo E, Kohler M, Morawieltz G, Cardesa A, Tomatis L, Mohr U. Ki-ras gene mutations and absence of p53 gene mutations in spontaneous and urethane-induced early lung lesions in CBA/J mice. Molecular Carcinogenesis, 21:251-260, 1998.
  • Tórtola S, Capellà G, Marcuello E, Günther K, Aiza G, Masramon L, Reymond MA, Peinado MA. Analysis of differential gene expression in human colorectal tumor tissues by RNA Arbitrarily Primed PCR: A technical assessment. Laboratory Investigation, 78: 309-317, 1998.

1997

  • Reymond MA, Sanchez JC, Schneider C, Rohwer P, Tortola S, Peinado MA, Hochstrasser D, Kirchner T, Hohenberger W, Köckerling F. Phenotypical analysis in colorectal carcinoma: an international interdisciplinary project. Lagenbecks Arch Chir, Suppl II: 1090-1092, 1997.
  • Reymond MA, Sanchez JC, Hugues GJ, Günther K, Riese J, Tortola S, Peinado MA, Kirchner T, Hohenberger W, Hochstrasser DF, Köckerling F. Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis. Electrophoresis, 18: 2842-2848, 1997.
  • Arribas R, Capellà G, Tórtola S, Masramon L, Grizzle W, Perucho M, Peinado MA. Assessment of Genomic Damage in Colorectal Cancer by DNA Fingerprinting: Prognostic Applications. Journal of Clinical Oncology, 15: 3230-3240, 1997.

1996

  • Sierra A, Castellsagué X, Tórtola S, Escobedo A, Lloveras B, Peinado MA, Moreno A, Fabra A. Apoptosis-Loss abd Bcl-2 Expression: Key determinants of Lymph Node Metastases in T1 Breast Cancer. Clinical Cancer Research, 2: 1887-1894, 1996.
  • Hernandez L, Fest T, Cazorla M, Teruya-Feldstein J, Bosch F, Peinado MA, Piris MA, Montserrat E, Cardesa A, Jaffe ES, Campo E, Raffeld M. p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas. Blood, 87: 3351-3359, 1996.

1995

  • Perucho M, Welsh J, Peinado MA, Ionov Y, McClelland M. Fingerprinting of DNA and RNA by arbitrarily primed PCR: Applications in cancer Research. Methods in Enzymology 254: 275-290, 1995.

1994

  • Nájera I, Richman D.D, Olivares I, Rojas J.M, Peinado MA, Perucho M, Nájera R, López-Galindez C. Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates. AIDS Research and Human Retrovirus 10: 1479-1488, 1994.
  • Berrozpe G, Schaeffer J, Peinado MA, Real FX, Perucho M. Comparative analysis of mutations in the p53 and K-ras genes in pancreas cancer. International Journal of Cancer 58: 185-191, 1994.
  • Shibata D, Peinado MA, Ionov Y, Malkhosyan S, Perucho M. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nature Genetics 6: 273-281, 1994.

1993

  • Schaeffer J, Capella G, Peinado MA, Fernandez-Renart M, Perucho M. Comparative analysis of the spectrum of genetic alterations in pancreatic and other carcinomas. International Journal of Pancreatology 14: 75-77, 1993.
  • Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363: 558-561, 1993.
  • Peinado MA, Fernández-Renart M, Capellà G, Wilson L, Perucho M. Mutations in the p53 suppressor gene do not correlate with c-K-ras oncogene mutations in colorectal cancer. International Journal of Oncology 2: 123-134, 1993.

1992

  • Peinado MA, Malkhosyan S, Velazquez A, Perucho M. Isolation and characterization of allelic losses and gains in colorectal tumors by Arbitrarily Primed Polymerase Chain Reaction. Proceedings of the National Academy of Sciences USA, 89: 10065-10069, 1992.
  • Puig-Domingo M, Webb S.M, Serrano J, Peinado MA, Corcoy R, Ruscadella J, Reiter R.J, DeLeiva A. Brief report: Melatonin-Related Hypogonadotrophic Hypogonadism. New England Journal of Medicine 327: 1356-1359, 1992.

1991

  • Monés J, Webb SM, Binimelis J, Matías-Guiu X, Peinado M.A, Ferré A. Circulating hypersomatostatinaemia in Menetrier’s disease. Hormone & Metabolism Research 23: 146-147, 1991.
  • Capellá G, Cronauer-Mitra S, Peinado MA, Perucho M. Frequency and spectrum of mutations at codon 12 and 13 of the C-K-ras gene in human tumors. Environmental Health Perspectives 93:125-131, 1991.

1990

  • Viader M, Peinado MA, Murcia M, Matias-Guiu X, Puig-Domingo M, Hernández G, Prat J, Webb SM. Immunohistochemical distribution and possible origins of somatostatin-like material in the bovine pineal gland. Neuroendocrinology Letters 12: 5-10, 1990.
  • De Leiva A, Tortosa F, Peinado MA, Serrano J, Rodríguez-Espinosa J, Puig-Domingo M. Episodic nyctohemeral secretion of melatonin in adult humans: Lack of relation with LH pulsatile pattern. Acta Endocrinologica 122: 76-82, 1990.
  • Peinado MA, Fajardo N, Hernández G, Puig-Domingo M, Viader M, Reiter R.J, Webb SM. Immunoreactive somatostatin diurnal rhythms in rat pineal, retina and Harderian gland: Effects of sex, season, continuous darkness and estrus cycle. Journal of Neural Transmission 81: 63-72, 1990.

1989

  • Peinado MA, Viader M, Puig-Domingo M, Hernández G, Reiter RJ, Webb SM. Regional distribution of immunoreactive somatostatin in the bovine pineal gland. Neuroendocrinology 50: 550-554, 1989.
  • Tortosa F, Puig-Domingo M, Peinado MA, Oriola J, Webb SM, de Leiva A. Enhanced circadian rhythm of melatonin in anorexia nervosa. Acta Endocrinologica 120: 574-578, 1989.

1988

  • Peinado MA, Viader M, Puig-Domingo M, Fabra A, Webb SM. Liberación y posible síntesis de somatostatina inmunorreactiva por la glándula pineal de rata “in vitro”. Endocrinología 35: 207-210, 1988.
  • Puig M, Peinado MA, Viader M, Martí R, Gabarró I, Webb SM. Regulación circadiana de la somatostatina retiniana en la rata. Annals de l’Hospital de la Santa Creu i Sant Pau 9: 132 134, 1988.
  • Puig-Domingo M, Guerrero JM, Reiter RJ, Peinado MA, Sabry I, Viader M, Webb SM. Identification of Immunoreactive somatostatin in the rat Harderian gland. Regulation of its content by Growth hormone, beta-adrenergic agonists and calcium channel blockers. Peptides 9: 571-574, 1988.
  • Puig-Domingo M, Guerrero JM, Reiter RJ, Peinado MA, Menendez-Pelaez A, Webb SM. Androgenic control of immunoreactive somatostatin in the Harderian gland of the syrian hamster. Journal of Reproduction and Fertility 82: 753-759, 1988.
  • Webb SM, Peinado MA, Puig-Domingo ML, Viader M, Reiter RJ. Rhythms in pineal immunoreactive somatostatin in the Syrian hamster, mouse and gerbil. Journal of Pineal Research 5: 273-278, 1988.

1987

  • Binimelis J, Webb SM, Monés J, Serrano J, Casamitjana R, Elena M, Peinado MA, Vilardell F, Leiva A. Circulating immunoreactive somatostatin in gastrointestinal diseases: decrease after vagotomy and enhancement in active ulcerative colitis, irritable bowel syndrome, and duodenal ulcer. Scandinavian Journal of Gastroenterology, 22:931-937, 1987.
  • Binimelis J, Webb SM, Serrano J, Codina M, Pérez A, Peinado MA, Serrat J, Gómez JA, Casamitjana R, Leiva A. Plasma immunoreactive somatostatin is elevated in diabetic ketoacidosis and correlates with plasma non-esterified fatty acid concentration. Diabetic Medicine 4:221-224, 1987

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